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血管內(nèi)皮功能診斷:循環(huán)系統(tǒng)疾病管理的評(píng)價(jià)指標(biāo)與實(shí)踐

血管內(nèi)皮功能診斷:循環(huán)系統(tǒng)疾病管理的評(píng)價(jià)指標(biāo)與實(shí)踐

作者：王宏宇
出版社：北京大學(xué)醫(yī)學(xué)出版社出版時(shí)間：2020-12-01
開(kāi)本： 其他 頁(yè)數(shù)： 89
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血管內(nèi)皮功能診斷:循環(huán)系統(tǒng)疾病管理的評(píng)價(jià)指標(biāo)與實(shí)踐 版權(quán)信息

血管內(nèi)皮功能診斷:循環(huán)系統(tǒng)疾病管理的評(píng)價(jià)指標(biāo)與實(shí)踐 內(nèi)容簡(jiǎn)介

本書分為7個(gè)大章節(jié)，分別為：血管內(nèi)皮功能總論、血管內(nèi)皮功能檢測(cè)方法、血管內(nèi)皮功能檢測(cè)所提供的信息、血管內(nèi)皮功能異常導(dǎo)致的疾病發(fā)展因素、血管內(nèi)皮功能提供的臨床依據(jù)、心血管疾病與血管內(nèi)皮功能的相關(guān)因素、臨床中血管內(nèi)皮功能應(yīng)用實(shí)踐。目前心血管疾病已成為人類健康的**殺手，血管健康與心血管健康息息相關(guān)，血管健康正是確保身體健康長(zhǎng)壽的關(guān)鍵。本書覆蓋了血管健康的基礎(chǔ)理論、臨床診斷、應(yīng)用實(shí)踐等方面，匯集了多個(gè)相關(guān)領(lǐng)域的醫(yī)生和學(xué)者的智慧，力求提供血管內(nèi)皮功能的基礎(chǔ)知識(shí)以及全新的臨床知識(shí)。

血管內(nèi)皮功能診斷:循環(huán)系統(tǒng)疾病管理的評(píng)價(jià)指標(biāo)與實(shí)踐 目錄

**章　血管內(nèi)皮功能總論 ···············································································1
一、血管內(nèi)皮細(xì)胞的作用 ················································································1
二、血管內(nèi)皮功能異常的機(jī)制 ··········································································3
三、血管內(nèi)皮功能異常反映出的問(wèn)題 ·································································9
四、血管內(nèi)皮功能檢測(cè)的臨床應(yīng)用 ·································································· 10
五、血管內(nèi)皮功能障礙到動(dòng)脈硬化 ·································································· 12
六、血管內(nèi)皮功能異常導(dǎo)致冠狀動(dòng)脈痙攣性心絞痛 ············································· 15
七、當(dāng)前血管內(nèi)皮功能為何受到關(guān)注？ ···························································· 16
八、血管內(nèi)皮功能在循環(huán)系統(tǒng)預(yù)防醫(yī)學(xué)中的定位 ················································ 16
第二章　血管內(nèi)皮功能檢測(cè)技術(shù) ······································································· 21
一、體積描記法 ·························································································· 21
二、 基于血管超聲檢測(cè)的血流介導(dǎo)的血管擴(kuò)張 ··················································· 21
三、 可替代FMD 的踝肱指數(shù)輕度異常值 ·························································· 22
四、 指端脈搏波反應(yīng)性充血外周動(dòng)脈張力 ························································· 23
五、FMD 與RHI 的區(qū)別 ··············································································· 24
六、前臂充血與上臂充血 ·············································································· 25
七、反映血管內(nèi)皮功能的生物標(biāo)志物 ······························································· 25
八、冠狀動(dòng)脈的內(nèi)皮功能 ·············································································· 28
第三章　血管內(nèi)皮功能檢測(cè)所提供的信息 ··························································· 31
一、血管內(nèi)皮功能檢測(cè)的篩查作用 ·································································· 31
二、血管內(nèi)皮功能檢測(cè)是動(dòng)脈硬化進(jìn)程的評(píng)價(jià)指標(biāo) ············································· 31
三、預(yù)測(cè)冠狀動(dòng)脈疾病的預(yù)后 ········································································ 32
四、冠狀動(dòng)脈痙攣性心絞痛的診斷 ·································································· 33
五、心臟微血管障礙的診斷與療效評(píng)估 ···························································· 33
六、深靜脈血栓癥的篩查 ·············································································· 34
七、預(yù)測(cè)外周動(dòng)脈疾病的預(yù)后 ········································································ 35
目　錄
2　血管內(nèi)皮功能診斷——循環(huán)系統(tǒng)疾病管理的評(píng)價(jià)指標(biāo)與實(shí)踐
第四章　血管內(nèi)皮功能障礙相關(guān)疾病的發(fā)病機(jī)制 ·················································· 39
一、一氧化氮 ····························································································· 39
二、炎癥 ··································································································· 40
三、氧化應(yīng)激 ····························································································· 40
四、自主神經(jīng) ····························································································· 42
第五章　血管內(nèi)皮功能提供的臨床依據(jù) ······························································ 45
一、血管內(nèi)皮功能相關(guān)的基礎(chǔ)研究 ·································································· 45
二、血管內(nèi)皮功能的臨床研究 ········································································ 46
第六章　心血管病及血管內(nèi)皮功能的相關(guān)因素 ····················································· 51
一、冠狀動(dòng)脈疾病家族史 ·············································································· 51
二、少鹽 ··································································································· 51
三、吸煙 ··································································································· 52
四、高血壓 ································································································ 52
五、糖尿病、糖代謝異常 ·············································································· 53
六、脂質(zhì)異常 ····························································································· 54
七、高尿酸血癥 ·························································································· 55
八、慢性腎病 ····························································································· 55
九、肥胖、代謝綜合征 ················································································· 56
十、睡眠呼吸暫停綜合征 ·············································································· 57
十一、運(yùn)動(dòng)、體育鍛煉 ················································································· 57
十二、高齡與性別 ······················································································· 59
十三、心律不齊 ·························································································· 59
十四、動(dòng)脈硬化性疾病 ················································································· 59
十五、靜脈血栓栓塞癥 ················································································· 61
十六、心力衰竭 ·························································································· 63
十七、肺動(dòng)脈高壓 ······················································································· 64
十八、血流動(dòng)力學(xué)狀態(tài) ················································································· 64
十九、抑郁癥 ····························································································· 65
二十、維生素、礦物質(zhì) ················································································· 65
二十一、不飽和脂肪酸 ················································································· 66
第七章　血管內(nèi)皮功能在臨床中的應(yīng)用實(shí)踐 ························································ 73
一、肥胖患者的減重指導(dǎo) ·············································································· 74
　目　錄　3
二、預(yù)防動(dòng)脈硬化的心血管疾病管理 ······························································· 74
三、心臟康復(fù)的風(fēng)險(xiǎn)分層與效果評(píng)價(jià) ······························································· 77
四、評(píng)價(jià)預(yù)防缺血性心臟病復(fù)發(fā)的干預(yù)治療效果 ················································ 78
五、心力衰竭的療效評(píng)價(jià) ·············································································· 79
六、預(yù)測(cè)心血管不良事件的發(fā)生 ····································································· 80
后記············································································································ 83
縮略詞一覽表································································································ 84
索引············································································································ 88
作者簡(jiǎn)介······································································································ 90

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血管內(nèi)皮功能診斷:循環(huán)系統(tǒng)疾病管理的評(píng)價(jià)指標(biāo)與實(shí)踐 作者簡(jiǎn)介

王宏宇，男，漢族，1967年12月出生，山西大同人，醫(yī)學(xué)博士，北京大學(xué)教授，心臟和血管醫(yī)學(xué)專業(yè)主任醫(yī)師，博士/碩士生導(dǎo)師。國(guó)家重點(diǎn)研發(fā)計(jì)劃“高可信強(qiáng)智能的心腦血管疾病診療服務(wù)模式解決方案”課題負(fù)責(zé)人，北京大學(xué)首鋼醫(yī)院副院長(zhǎng)兼血管醫(yī)學(xué)中心主任，北京大學(xué)醫(yī)學(xué)部血管健康研究中心主任，北京大學(xué)醫(yī)學(xué)部血管疾病社區(qū)防治中心主任，北京大學(xué)臨床研究所心臟和血管健康研究中心主任，分子心血管學(xué)教育部重點(diǎn)實(shí)驗(yàn)室特聘教授，北京大學(xué)醫(yī)學(xué)部睡眠醫(yī)學(xué)中心和北京大學(xué)睡眠研究中心專家委員會(huì)委員，北京大學(xué)醫(yī)學(xué)部血管醫(yī)學(xué)、北京大學(xué)血管探秘課程教研室主任。1997年開(kāi)始進(jìn)行血管功能研究，2004年作為國(guó)家衛(wèi)生部十年百項(xiàng)計(jì)劃“血管病變?cè)缙跈z測(cè)技術(shù)推廣”項(xiàng)目負(fù)責(zé)人，在國(guó)際上率先提出血管病變?cè)缙跈z測(cè)系統(tǒng)，組織制訂了國(guó)際上第一個(gè)血管病變?cè)缙跈z測(cè)技術(shù)應(yīng)用指南，2010年4月創(chuàng)建了我國(guó)第一家血管醫(yī)學(xué)專業(yè)臨床診療中心—北京大學(xué)首鋼醫(yī)院血管醫(yī)學(xué)中心，2011年和2019年分別主持我國(guó)針對(duì)血管健康管理與預(yù)后心血管疾病關(guān)系的人群隊(duì)列研究和多中心臨床干預(yù)研究（BEST，NCT02569268；EndoFIND，NCT04013204）。目前已發(fā)表學(xué)術(shù)文章240余篇，其中SCI收錄文章26篇。主編我國(guó)第一部血管醫(yī)學(xué)領(lǐng)域?qū)Ｖ堆懿W(xué)》（北京：人民軍醫(yī)出版社，2006）和《中國(guó)血管健康行科普系列叢書》（共8冊(cè)）（北京：北京大學(xué)醫(yī)學(xué)出版社，2011）等著作10余部。主持和負(fù)責(zé)多項(xiàng)北京市和國(guó)家科研項(xiàng)目。獲“北京市優(yōu)秀人才”稱號(hào)，為北京大學(xué)醫(yī)學(xué)部?jī)?yōu)秀教師、首屆北京大學(xué)“臨床醫(yī)療獎(jiǎng)”獲得者。目前擔(dān)任國(guó)際血管健康學(xué)會(huì)（International Society of Vascular Health，ISVH）執(zhí)行委員會(huì)委員，國(guó)際血管健康學(xué)會(huì)中國(guó)分會(huì)主席，美國(guó)高血壓學(xué)會(huì)院士（Fellow of American Society of Hypertension，F(xiàn)ASH），中國(guó)醫(yī)藥教育協(xié)會(huì)血管醫(yī)學(xué)專業(yè)委員會(huì)主任委員，中日醫(yī)學(xué)科技交流協(xié)會(huì)心臟和血管醫(yī)學(xué)專業(yè)委員會(huì)主任委員，中國(guó)心臟和血管健康學(xué)院院長(zhǎng)，中央電視臺(tái)紀(jì)錄頻道（CCTV-9）和《健康之路》欄目、北京電視臺(tái)《健康北京》和《養(yǎng)生堂》欄目特邀專家，《中國(guó)循環(huán)雜志》等國(guó)內(nèi)外多家專業(yè)雜志的編委。

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